Risking their lives on the job and wearing their hearts on their sleeves, the case-cracking colleagues Jane Rizzoli (Angie Harmon) and Dr. Maura Isles (Sasha Alexander) face every challenge with brains, brawn, humor and fierce loyalty to the friendship that makes it all worthwhile. Based on the best selling novels by Tess Gerritsen. 105 episodes, 77 hrs, 24 DVDs.